New clue to causes of amyotrophic lateral sclerosis (ALS)
I am curious how many varieties of ALS there are.
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About
Schematic of spinal cord wiring
I am with the Lahey Neurosciences Simulation Group working on software that models neurological disorders and their treatment. Our PI, neurosurgeon Dr. Jeffrey Arle, designed software that models neural circuits down to the synapse. The group has previously modeled Deep Brain Stimulation for Parkinson’s Disease in the subthalamic nucleus, motor cortex stimulation, and the operation of the cochlear nucleus.
We have built the world’s most complete model of the spinal cord and are calibrating it with simple reflexes. Next we will model the pain-reducing effect of an electrical stimulator on the cord.
My role in this project is software architecture, CAD design of the spinal cord and electrical stimulators (with SolidWorks), finite element analysis of the effect of the stimulators on the spinal cord (with COMSOL), and general pre- and post-processing with Mathematica.
Other members of the group are Dr. Jay Shils (electrical engineer and neurophysiologist), Longzhi Mei (programmer), and Nick Iftemia (spinal cord research).
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