Kris Carlson

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Abstract | Transgenic Mouse Model for the Formation of Hirano Bodies

 

Mice with Hirano bodies appear healthy and fertile, but exhibited some alterations in both short-term and long-term synaptic plasticity, including paired-pulse depression rather than facilitation, and decreased magnitude of early LTP.

Conclusions

Hirano bodies are not lethal and appear to have little or no effect on histology and tissue organization. Hirano bodies do modulate synaptic plasticity and exert clearly discernable effects on LTP and paired-pulse paradigms. This model system will allow us to investigate the impact of Hirano bodies in vivo, the pathways for formation and degradation of Hirano bodies, and whether Hirano bodies promote or modulate development of pathology and disease progression.

Abstract | Transgenic Mouse Model for the Formation of Hirano Bodies.

October 18, 2011 Posted by | Biogerontology, CNS Disorders, Disease and Disorder | Leave a comment

New clue to causes of amyotrophic lateral sclerosis (ALS)

 

 

 

I am curious how many varieties of ALS there are.

BioMed Central | Full text | A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function.

October 18, 2011 Posted by | CNS Disorders, Disease and Disorder | Leave a comment

Koan

Yanyang asked Zhaozhou, “I don’t bring a single thing.”

Zhaozhou said, “Put it down.”

Yanyang said, “Put what down?”

Zhaozhou said, “Then pick it up.”

–Quoted in Cleary, Meditating with Koans

October 10, 2011 Posted by | Zen | , , , , , | Leave a comment

Koan

A student asks a Teacher, “When will I have enlightenment?”

The Teacher replies, “When you understand it is Today.”

October 10, 2011 Posted by | Zen | , , , | Leave a comment

Koan

Liang Wudi, Emperor of South China, asked Bodhidharma, “What is the highest meaning of the holy truths?”

Bodhidharma said, “That they are without holiness.”

–Quoted in Cleary, Meditating with Koans.

October 9, 2011 Posted by | Zen | , , , , | Leave a comment

Koan

Zhaozhou said, “Finding the Ultimate Path is not difficult. Just avoid picking and choosing.”

–Quoted in Cleary, Meditating with Koans.

October 9, 2011 Posted by | Zen | , , , , | Leave a comment

Koan

A monk named Huichao asked Fayan, “What is Buddha?”

Fayan replied, “You are┬áHuichao.”

–Quoted in Cleary, Meditating with Koans.

October 9, 2011 Posted by | Zen | , , , , | Leave a comment

Koan

Zhaozhou asked Touzi, “When one has died the great death in what fashion does he return to earth?”
Touzi said, “He must return in broad daylight.”

–Quoted in Cleary, Meditating with Koans

October 9, 2011 Posted by | Zen | , , , , , | Leave a comment

Koan

A monk asked Yunmen, “What is pure Dharmakaya?”
Yunmen said, “A flowering hedge.”

October 9, 2011 Posted by | Zen | , , , , | Leave a comment

Koan

Heshan imparted this saying: “Practicing and studying is called ‘learning.’ Being at the end of your studies is called ‘being close.’ Going beyond these two is real going beyond.”
A monk came forward and asked, “What is real going beyond.”
Heshan said, “Knowing how to beat the drum.”
The monk asked, “What is the real truth?”
Heshan said, “Knowing how to beat the drum.”
The monk asked, “When a transcendant being comes, how to you receive him?”
Heshan said, “Knowing how to beat the drum.”
–Quoted in Cleary, Meditating with Koans

October 9, 2011 Posted by | Zen | , , , , | Leave a comment

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