Kris Carlson

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Abstract | Transgenic Mouse Model for the Formation of Hirano Bodies

 

Mice with Hirano bodies appear healthy and fertile, but exhibited some alterations in both short-term and long-term synaptic plasticity, including paired-pulse depression rather than facilitation, and decreased magnitude of early LTP.

Conclusions

Hirano bodies are not lethal and appear to have little or no effect on histology and tissue organization. Hirano bodies do modulate synaptic plasticity and exert clearly discernable effects on LTP and paired-pulse paradigms. This model system will allow us to investigate the impact of Hirano bodies in vivo, the pathways for formation and degradation of Hirano bodies, and whether Hirano bodies promote or modulate development of pathology and disease progression.

Abstract | Transgenic Mouse Model for the Formation of Hirano Bodies.

October 18, 2011 - Posted by | Biogerontology, CNS Disorders, Disease and Disorder

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